This track shows gene predictions using the N-SCAN gene structure prediction
software provided by the Computational Genomics Lab at Washington University
in St. Louis, MO, USA.
N-SCAN combines biological-signal modeling in the target genome sequence along
with information from a multiple-genome alignment to generate de novo
gene predictions. It extends the TWINSCAN target-informant genome pair to allow for
an arbitrary number of informant sequences as well as richer models of
sequence evolution. N-SCAN models the phylogenetic relationships between the
aligned genome sequences, context-dependent substitution rates, insertions,
For creating predictions on cow, N-SCAN uses mouse (mm9) as the informant.
N-SCAN PASA-EST combines EST alignments into N-SCAN. Similar to the conservation
sequence models in TWINSCAN, separate probability models are developed for EST
alignments to genomic sequence in exons, introns, splice sites and UTRs,
reflecting the EST alignment patterns in these regions. N-SCAN PASA-EST is more
accurate than N-SCAN while retaining the ability to discover novel genes to
which no ESTs align.
No manual annotation was performed to generate any of the gene models.